The Gut-Brain Connection...

In an 1817 study on Parkinson’s disease (PD), James Parkinson noted that many of the patients with PD had gastrointestinal issues, and that up to 80% of these patients suffered from constipation. Even 200 years ago, we knew about the gut-brain connection. Currently, the literature demonstrates that the microbiome does, in fact, affect the function of the brain; the development of the brain, the activity of circuits in the brain, and certain behaviors. The research has mainly focused on identifying specific molecules made by gut bacteria, and how they mediate the gut-brain connection.

gut brain connection cartoon

In a recent study, the question was posed, “Why do people with neurological conditions have GI issues?” Because the microbiomes are different between a PD patient and a healthy patient, they transplanted the microbiota from the human PD patients into germ-free mice. The mice, as you might expect, developed severe PD symptoms, confirming their theory that the microbiome was contributing to the symptoms.

Whether or not the microbiome is responsible for inducing PD is “complete speculation,” as stated by the author of the study. However, they think that it is certainly possible. He also noted that decoding the microbiome will be a “blueprint that will uncover the microbiome as an avenue to understand health and disease and leverage it to people.”

In other words, the microbiome will continually be assessed to help demystify its influence on neurological diseases such as PD.

In addition, the researchers identified the genes that are responsible for inducing PD symptoms and recognized that these genes dictate microbial pathways. Their first clinical trial will begin at the end of the year, employing “a gut-selective molecule that targets a microbial pathway, which is completely inert to the mammalian system, in about 100 PD patients.”


  1. Caleb Berkoff on March 15, 2019 at 11:55 am

    I think you have mentioned some very interesting points, thankyou for the post.

  2. Caroline Friede on March 18, 2019 at 4:51 am

    I got what you mean ,saved to bookmarks, very decent site.

  3. nagels breda on May 14, 2019 at 10:03 am

    Hmm it appears like your blog ate my first comment (it was
    super long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog.
    I as well am an aspiring blog blogger but I’m still new to everything.
    Do you have any tips and hints for rookie blog writers? I’d certainly appreciate it.

  4. accountant on May 16, 2019 at 7:42 pm

    I enjoy what you guys tend to be up too. Such clever work and coverage!
    Keep up the wonderful works guys I’ve added you guys to my own blogroll.

  5. loonadministratie uitbesteden breda on May 21, 2019 at 1:40 pm

    I’m not sure where you’re getting your information, but great topic.

    I needs to spend some time learning much more or understanding more.
    Thanks for great information I was looking for this information for my mission.

  6. on June 9, 2019 at 5:31 pm

    I don’t even know how I ended up here, but I thought this post
    was good. I don’t know who you are but certainly you’re going to a famous blogger
    if you are not already 😉 Cheers!

    • Alex on June 24, 2019 at 5:42 pm

      Thank you for the kind feedback!

  7. on June 29, 2019 at 5:09 am

    Enjoyed reading through this, very good stuff, thanks.

  8. on June 29, 2019 at 7:08 pm

    Some truly interesting info, well written and loosely user pleasant.

  9. Would love to incessantly get updated outstanding site!

  10. This site was… how do I say it? Relevant!!
    Finally I’ve found something which helped me. Many thanks!

  11. on July 2, 2019 at 8:32 am

    Thanks for the sensible critique. Me and my neighbor were just preparing to do some research on this.
    We got a grab a book from our local library but I think I learned more
    from this post. I am very glad to see such excellent
    info being shared freely out there.

  12. I want to to thank you for this wonderful read!! I absolutely loved every little bit of it.
    I have you book-marked to look at new things you post!

  13. on July 5, 2019 at 4:57 am

    Nice post. I learn something totally new and challenging on sites
    I stumbleupon everyday. It will always be exciting to read articles from other authors and practice a little something from other websites.

  14. Thankfulness to my father who stated to me concerning
    this blog, this blog is genuinely remarkable.

  15. on July 9, 2019 at 12:19 am

    Hello.This article was extremely interesting, especially because I was investigating for thoughts on this matter last Tuesday.

    • admin on July 9, 2019 at 7:09 am

      We’re happy you found your way to our blog! Thanks for the feedback.

  16. on July 16, 2019 at 8:30 am

    I needed to compose you this tiny word to help thank you the moment again regarding
    the incredible opinions you have discussed at
    this time. It’s certainly extremely generous
    of you to give unhampered what exactly many people might have
    offered as an electronic book to earn some money for themselves, most notably
    considering the fact that you could possibly have tried it in the event you
    decided. These solutions likewise worked as a good
    way to comprehend someone else have the identical keenness really
    like my very own to understand significantly more with regards
    to this problem. I believe there are a lot more pleasurable moments up front for
    people who look into your website.

  17. Donte on July 16, 2019 at 8:43 pm

    Thanks in favor of sharing such a nice thinking, piece
    of writing is fastidious, thats why i have read it entirely

  18. I truly value your piece of work, Great post.

  19. There is apparently a bunch to realize about this. I feel you made some nice
    points in features also.

  20. I am continually looking online for ideas that can aid me.

  21. hemorrhoids help on July 24, 2019 at 11:41 pm

    Excellent way of describing, and good paragraph to get data about my presentation subject matter,
    which i am going to convey in institution of higher education.

  22. Live Show on July 25, 2019 at 4:43 pm

    Do you mind if I quote a few of your articles as long as I provide credit and sources back to your
    weblog? My blog site is in the exact same niche as yours and my users would truly benefit from some of the information you provide here.
    Please let me know if this okay with you. Cheers!

    • admin on July 25, 2019 at 11:53 pm

      Of course! The purpose of our blog is to freely exchange and share beneficial information/opinions to others. We appreciate you sharing!

  23. Free Cams on July 28, 2019 at 1:52 am

    I think the admin of this site is in fact working hard
    in favor of his web page, because here every stuff is quality based data.

    • admin on July 29, 2019 at 7:20 pm

      The Admin appreciates you noticing her hard work! -Thank you 🙂

  24. Heavy Lifting on August 1, 2019 at 3:36 am

    You’re so awesome! I do not believe I’ve truly read through something like
    this before. So nice to discover somebody with original thoughts on this subject
    matter. Really.. thank you for starting this up.
    This site is something that is required on the internet, someone
    with a little originality!

  25. Life Experience Degrees on August 7, 2019 at 6:29 pm

    whoah this weblog is excellent i really like reading your articles. Keep up the good work! You already know, a lot of persons are looking round for this information, you could help them greatly.

    • admin on August 7, 2019 at 11:34 pm

      Thanks for the great feedback! How did you find our blog?

  26. Life Experience Degree on August 7, 2019 at 6:30 pm

    Thanks for an explanation. All ingenious is simple.

  27. Phil on August 9, 2019 at 9:12 pm

    I’m not that much of a online reader to be honest but your blogs really
    nice, keep it up! I’ll go ahead and bookmark your site to come back in the future.

    Many thanks

  28. on August 14, 2019 at 6:06 am

    I could not refrain from commenting. Exceptionally well

  29. Donut Damien on August 16, 2019 at 10:59 am

    Just want to say your article is as astonishing. The
    clearness for your publish is simply cool and that i could assume you’re knowledgeable in this subject.

    Fine along with your permission allow me to grab your feed to keep up to date with forthcoming post.
    Thank you 1,000,000 and please carry on the enjoyable work.

  30. Brock on August 18, 2019 at 5:45 pm

    Saved as a favorite, I like your website!

Leave a Comment